Modeling antibiotic resistance in hospitals: The impact of minimizing treatment duration

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Modeling antibiotic resistance in hospitals: the impact of minimizing treatment duration.

Infections caused by antibiotic-resistant pathogens are a global public health problem. Numerous individual- and population-level factors contribute to the emergence and spread of these pathogens. An individual-based model (IBM), formulated as a system of stochastically determined events, was developed to describe the complexities of the transmission dynamics of antibiotic-resistant bacteria. T...

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Antibiotic control of antibiotic resistance in hospitals: a simulation study

BACKGROUND Using mathematical deterministic models of the epidemiology of hospital-acquired infections and antibiotic resistance, it has been shown that the rates of hospital-acquired bacterial infection and frequency of antibiotic infections can be reduced by (i) restricting the admission of patients colonized with resistant bacteria, (ii) increasing the rate of turnover of patients, (iii) red...

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ژورنال

عنوان ژورنال: Journal of Theoretical Biology

سال: 2007

ISSN: 0022-5193

DOI: 10.1016/j.jtbi.2007.08.011